Hemopoietic growth factor are protein hormones that maintain the microenvironment of bone marrow. They are produced by lymphocytes, monocytes, macrophages, endothelial cells and fibroblasts. Some control the multiplication and differentiation of stem cells into mature circulating cells others affects the function of mature cells in response to infection. Growth factors can be classified according to their affect:
[1] Non-lineage-specific growth factor act on pluripotential and multipotential stem cells to initiate self renewal and differentiation. E. g. Interlukin-3 (IL-3) induces the formation of colonies of granulocytes, monocytes, eosinophils, mast cells, erythroid cells, and megakaryocytes.
[2] Lineage-specific growth factor act on the committed progenitor cells and are involved in the differentiation and maturation of blood cells in the later stages of blood cell maturation. E. g. Granulocytes CSF (G-CSF), macrophages CSF (M-CSF), eosinophils CSF (Eo-CSF), erytropoietin (Epo) and thrombopoietin.
[3] Cytokines are chemical messengers released by certain cells to "communicate" with other cells. E. g. Interleukin-1 (IL-1) is released by monocytes. It stimulates T-helper cells to proliferate and produce mature T-cells that release their own growth promoting factor.
Title : Hemopoietic Growth Factor
Description : Hemopoietic growth factor are protein hormones that maintain the microenvironment of bone marrow. They are produced by lymphocytes, monocyte...
